Nuclear Magnetic Resonance
The Nuclear Magnetic Resonance (NMR) Core Facility at the National and Kapodistrian University of Athens is part of the horizontal infrastructure of the School of Sciences. The purpose of the facility is to serve the research interests of the academic community, and all other interested parties, in the field of Nuclear Magnetic Resonance. Collaborations including joint publications, research proposals, and funding are highly encouraged. Moreover, the goal of the NMR Core Facility is to offer training in state-of-the-art NMR instrumentation and software. The available NMR systems are equipped with different state-of-the-art, highly sensitive probes for conducting experiments on liquid, solid and semi-solid samples. It is possible to study small molecules (e.g. drugs, synthetic compounds, natural products, etc.), polymers, as well as the interactions of small molecules with biomolecules (e.g. proteins, nucleic acids). The unit consists of two subunits: The 500 MHz and the 400 MHz NMR.
Staff
Head of Unit
Deputy Head of Unit
Principal Investigator
Principal Investigator
400 MHz NMR SUB UNIT
SERVICES
- Supports 1D & 2D experiments (¹H, ¹H with solvent suppression, ¹³C, ¹³C-DEPT, ¹⁵N, ³¹P, J-Resolved, COSY, HSQC-DEPT, HMQC, HMBC, TOCSY, NOESY, ROESY, CPMG, DOSY) and advanced NOAH & UTOPIA supersequences.
- Ideal for Physics, Chemistry, and Life Sciences, covering small molecule structure determination, qualitative & quantitative analysis, pharmaceuticals, biochemistry, and metabolomics (biological samples & plant extracts).
TECHNOLOGY AND EQUIPMENT
AVANCE NEO 400 MHz System
- This system features a 9.4 Tesla ASCEND superconducting magnet on a Bruker Avance NEO platform, equipped with a 24-position automatic sample changer (SampleCASE 24) and advanced transceivers, amplifiers, and pre-amplifiers (1H, BB19F, 2H and 10 A gradient amplifier) for high-performance NMR experiments.
- It includes a Bruker Smart Variable Temperature Control unit, BCU I Cooler, and a high-sensitivity iProbe detector (5 mm Smart Probe) with a wide temperature range (-150 °C to 150 °C) and high signal sensitivity across multiple nuclei (1H, 13C, 19F, 31P, 15N).
- Controlled by TopSpin 4, SmartDriveNMR, and CMC-assist for spectrum processing and integration.
AVANCE NEO 400 MHz
500 MHz NMR SUB UNIT
SERVICES
- The system supports routine 1D & 2D experiments (¹H, ¹³C, DEPT, J-resolved, COSY, HSQC, HMBC, TOCSY, NOESY, ROESY, DOSY) and advanced supersequences (NOAH, UTOPIA). It also enables detection of various nuclei (e.g., ⁷Li, ¹¹B, ¹⁵N, ¹⁹F, 27Al, ²⁹Si, ³¹P, ³⁹K, ⁷⁷Se, 79Br, 113Cd, 119Sn,¹⁹⁵Pt) and supports solid, semi-solid, and liquid samples with specialized probes.
- Ideal for applications in Chemistry, Physics, Life Sciences, and Metabolomics (Biological samples and plant extracts), including small molecule analysis (structure elucidation and quantitative analysis), polymer studies, structural biology, and pharmaceuticals.
TECHNOLOGY AND EQUIPMENT
AVANCE NEO 500 MHz System
- High field ASCEND Superconducting Magnet (11.76 Tesla)
- Cooled Automatic Sample Changer (SampleCASE Cooled 24) by BCU I Cooler
- & Transceivers, Signal Amplifiers, and pre-amplifiers (1H, BB19F, BB31P, 2H) )
- Temperature Control (Bruker Smart Variable Temperature Control)
- Cooling System (BCU II Cooler)
Available Detectors
Liquid State:
- PRODIGY BBO CryoProbe (5 mm): -40 °C to 150 °C, high sensitivity for ¹H, ¹³C, ¹⁹F, ³¹P, and ¹⁵N
- BBI Probe (5 mm): -150°C to 150°C, detects nuclei from ³¹P to ¹⁰⁹Ag
- Low-frequency BBO Probe (10 mm): -130 °C to 150 °C
Solid State:
- Solid-State iProbe (4 mm): -80 °C to 200 °C, up to 15 kHz spinning rate
Semi-solid State:
- HRMAS iProbe (4 mm): -30 °C to 80 °C, up to 15 kHz spinning rate
The system runs on TopSpin 4, with specialized software such as SmartDriveNMR, CMC-assist, CMC-ce, AssureNMR, and AMIX for advanced spectral processing and result integration.
AVANCE NEO 500 MHz
Book our Equipment
We look forward to supporting your research with the best tools and expertise available. Explore our resources and unlock new possibilities at NKUA Core Facilities today!
Availability
NKUA Users
You can use your NKUA account to book our equipment with a single click by using the button below.
External Users
Book our Equipment
We look forward to supporting your research with the best tools and expertise available. Explore our resources and unlock new possibilities at NKUA Core Facilities today!
Availability
NKUA Users
You can use your NKUA account to book our equipment with a single click by using the button below.